Pancreatic Dyspepsia: A Place for Pancreatic Insufficiency in Dyspepsia*

Dyspepsia refers to a condition of impaired digestion which has a yearly incidence of approximately 1%, and the prevalence of around 20-30%. Although the etiology of dyspepsia varies, an organic cause is found in only 40% of the patients. In the differential diagnosis of dyspepsia, cardiac, hepatobiliary, pancreatic, and intestinal disorders and gastroesophageal reflux disease can be eliminated as non-gastric causes. Inhibition of gastric acid secretion with proton pump inhibitors, use of an antidepressant drug in functional dyspeptic patients and prokinetics drugs are the approaches generally used in the treatment of dyspepsia regardless of the presence of gastric or non-gastric causes. Sometimes, despite all efforts, treatment of dyspepsia is unsuccessful. In those patients, pancreatic enzyme deficiency should be kept in mind and enzyme replacement therapy should be given.